Authors : U. Satya Devi, Madhur Gupta
Volume : 4
Issue : 3
Year : 2015
Page No : 171-175
ABSTRACT: Senile cataract is a multifactorial disease, but oxidative stress is considered to be most important risk factor. The aim of our study is to assess the levels of prooxidants by measuring the lipid peroxidation products in the form of the Malondialdehyde (MDA) and the antioxidant enzyme levels like Superoxide dismutase (SOD), Glutathione peroxidase (GPX) in the blood. A case control study was carried out in total number of 50 newly diagnosed cataract cases and 50 age matched controls. MDA, a marker of oxidative stress antioxidant enzymes Glutathione peroxidase (GPX) and Superoxide dismutase (SOD) were measured by enzymatic spectrophotometric method. Significantly increased levels of serum lipid peroxides in the form of MDA (P<0.001) were observed in cataract patients when compared to controls. Significantly decreased levels of SOD, GPX were observed in cataract patients as compared to normal healthy control (p<0.001). In the present study, it was concluded that oxidative stress plays an important role in the onset of senile cataract.