Authors : Amornyotin S, Chalayonnawin W, Kongphlay S
Volume : 5
Issue : 3
Year : 2016
Page No : 00142
This study was aimed to evaluate and compare the adverse event rate of pharyngeal anesthesia when the topical lidocaine is used as a single agent for unsedated esophagogastroduodenoscopy (UEGD) between healthy adults and cirrhotic patients. Retrospectively analyzed the patients on whom UEGD procedures had been performed during the period of June, 2008 to December, 2009 in Siriraj Hospital. Patients were categorized into two groups. Group A was the healthy adults. Group B was the cirrhotic patients. The primary outcome variable was the adverse event rate. Secondary outcome variables were anesthesia and procedure-related adverse events, and mortality rate. There were 1,398 patients who underwent UEGD procedure during the study period. After matching age, gender, weight, height and duration of procedure, there were 131 patients in group A and 129 patients in group B. All pharyngeal anesthesia was given by residents or anesthetic nurses directly supervised by staff anesthesiologist in the endoscopy room. There were no significant differences in age, gender, weight, height, duration of procedure, and overall adverse event rate between the two groups. Hypertension in group B was significantly greater than in group A. However, tachycardia and hypertension in group B was significantly lower than in group A. All adverse events were transient, easily treated, with no adverse sequelae. UEGD in healthy adults and cirrhotic patients was safe and effective. Although, overall adverse event rate was relatively high, however, all adverse events in both groups were comparable, mild degree, transient and easily treated. No serious adverse events were observed in these two groups.