Authors : Manju Chandankhede, Madhur Gupta
Volume : 4
Issue : 5
Year : 2016
Page No : 1823-1825
Abstract: Preeclampsia (PE) is a pregnancy specific syndrome characterized by new onset hypertension and proteinuria. The pathogenesis of preeclampsia involves a number of biological processes that may be directly or indirectly affected by antioxidants, vitamin D and beta carotene. We have estimated the role of vitamin D and beta carotene in 30 patients of preeclampsia (Group III) compared with 30 non pregnant (Group II) and 30 pregnant females (Group I). Beta carotene was estimated by spectroscopic method of Sobel and Snow and vitamin D was measured by High pressure liquid chromatography (HPLC). The levels of beta carotene (134.2+9.75 μg/dl vs 165.1+64.9 μg/dl and 173.1+51.7 μg/dl) and vitamin D (16.8+2.14 μg/l vs 31.6+9.33 μg/l and 32.4+7.34 μg/l) were significantly lower in group III as compared to group II and I [p< 0.001]. Also positive correlation between vitamin D and beta carotene patients was found in group III (correlation coefficient r=0.179294). Hence we concluded that PE patients had lower vitamin D and beta carotene levels and assessment of these parameters in pregnant women could be useful in the early identification of preeclampsia. Keywords: Preeclampsia, pregnancy, antioxidants, vitamin D, beta carotene.