Association between serum alpha-fetoproteinlevel and liver function parameters in hepatocellular carcinoma patients: A case-control study

Authors : Poornima R Varma

DOI : 10.18231/j.ijcbr.2023.030

Volume : 10

Issue : 2

Year : 2023

Page No : 176-178

Background: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer occurs in people with liver diseases like chronic hepatitis B and hepatitis C virus. Early diagnosis and monitoring of HCC is possible with the help of tumor marker AFP. The aim of the study was to assess whether AFP level is associated with selected liver function tests in hepatocellular carcinoma patients.
Materials and Methods: Total 90 individuals are selected, 50 HCC patients with AFP >20ng/ml and 40 subjects (normal LFT and AFP value <10ng> Result: Elevated levels of AFP (p value <0> Conclusion: From the study, it is concluded that LFT and AFP are comparatively elevated in HCC. Treatment is usually not possible with advanced HCC due to failure of not doing proper screening at appropriate time. Early diagnosis and monitoring of HCC are possible with the help of tumor marker AFP.
 

Keywords: Alpha- fetoprotein, Aspartate transaminase, Alanine transaminase, Tumor marker.


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