Authors : Latha Rani Muthireddy, Suresh Eadala*, Durga Prasad Vangara, Srihita Mahavadi
DOI : 10.18231/j.ijcbr.2023.021
Volume : 10
Issue : 2
Year : 2023
Page No : 129-133
Background: As there are very few studies in our region about the metabolic changes in hypothyroid and renal failure patients in collection of sample during various phases of time, where these organs were involved in regulating this metabolism.
Aim: To evaluate the trends of lipid profiles in hypothyroidism and chronic kidney disease throughout various phases of time.
Materials and Methods: This was a retrospective control study conducted on 50 CKD patients, 50 hypothyroidism patients and 50 controls in the tertiary care hospital attending to OPD. Collected samples are analyzed for Total cholesterol, Triglycerides, and HDL cholesterol whereas LDL and VLDL are measured by calculated method taken at various phases of time. The data was entered into the master chart and analyzed statistically.
Results: It was found that random lipid profile values in CKD and hypothyroidism were higher and are statistically significant compared to fasting and postprandial states. Particularly there is an elevation in Total cholesterol, Triglycerides, LDL cholesterol whereas HDL levels are decreased.
Conclusion: This research work is done by analyzing the fasting, postprandial and random states because it includes an explanation of why a random blood sample is preferred to analyze lipid profile values. Thyroid disease and renal failure patients are more prone to development of atherosclerosis which were primary cause for development of cardiovascular and cerebrovascular complications. So collection of the sample also plays key role in management.
Keywords: Dyslipidemia, CKD, Hypothyroidism, Lipid profile.