Authors : Amrutraj Patil, Rachana Lakhe, Rajeev Doshi, Preeti Doshi, Milind Kesarkhane, Ravindra Nimbargi
DOI : 10.18231/j.jdpo.2023.017
Volume : 8
Issue : 2
Year : 2023
Page No : 79-82
Background: Colorectal cancer is the third most common cancer in both men and women. Environmental and genetic factors play a role in the development of colorectal carcinomaThe majority of colorectal cancers are sporadic, with hereditary cancer syndrome accounting for 10% of cases. Precursor lesions like adenoma that transform into adenocarcinoma cause the majority of colorectal cancers.
Materials and Methods: A total of 72 of colorectal malignancies were studied for histopathological features. The histologic features were studied for site, grade, tumor -infiltrating lymphocytes, Crohn -like lymphocytic reaction, mucinous histology, signet ring cell histology, and medullary growth pattern.
Results: The mean age of the patients was 59.52 ± 11.80 years with M:F 1.76:1. Light microscopy showed TILs in 16 (22.2%) patients, followed by mucinous areas in 5 (6.9%), crohn like lymphocytic reaction in 4 (5.6%) and signet ring morphology in 2 (2.8%) patients.
Conclusion: This study concludes that colorectal carcinomas are more common in 5th and 6th decade of life with slight male preponderance. The most common malignant lesion being moderately differentiated adenocarcinomas. This study highlights age and gender prevalence, as well as histopathological characteristics of colorectal carcinomas in this demographic region .
Keywords: Colorectal cancer, MSI histology, hereditary cancer syndrome