Authors : T. S. Shailaja, A. Mohan Kumar, Rajan J. Payyappilly
DOI : 10.18231/2394-5478.2018.0009
Volume : 5
Issue : 1
Year : 0
Page No : 47-51
Introduction: Antimicrobial resistance (AMR) is a global menace of recent times which does not spare the uropathogenic bacteria also. We aim to study the changes in bacteriological profile and antibiotic resistance pattern among the bacterial isolates of Urinary tract infections (UTI) in a multi-centric study from two different tertiary care hospitals located in rural parts of Kerala in two different time periods.
Materials and Methods: First study was conducted from Jul 2008 – Jun 2009 and the second from May 2016 - Apr 2017.
Results: Total numbers of urine samples processed in the first and second study are 3262 and 3772, of which 1096 and 1265 respectively showed significant bacteriuria. The predominant isolate is E.coli in both, with a percentage of 50.8 and 48.9 respectively followed by Klebsiella sp. and Enterococcus sp. There is a marked increase in the resistance rate of E.coli to cefotaxime, piperacillin tazobactam and imipenem. In case of first line drugs, there is a minimal fall in resistance rate except for ciprofloxacin. Similarly for aminoglycosides there is no significant increase in resistance.
Conclusion: The high prevalence of resistance to empirical drugs has long been appreciated in this area which precludes their use. Resistance to higher antibiotics also is on the rise. Very high rate of AMR is exhibited by the bacterial agents of UTI even in rural areas which necessitates routine culture and sensitivity mandatory in all cases. In order to stop this growing menace, judicious use of antibiotics has to be implemented.
Keywords: Antimicrobial resistance, Multicentric, Rural Kerala, Trends, Uropathogens.