Design, synthesis and biological evaluation of novel thiadiazole derivatives as antihyperlipidemic agents

Authors : Paul Jacob, Beena Thomas, Neethu Santhosh

DOI : 10.18231/2394-2797.2018.0004

Volume : 5

Issue : 1

Year : 0

Page No : 16-23

Thiadiazole derivatives are reported to have various biological activities including antihyperlipidemia. In the present study a series of N-phenyl-1, 3, 4-thiadiazol-2-amine derivatives were designed using various softwares like Molinspiration, Schrodinger etc. The derivatives with optimum properties were synthesized and characterized using FT-IR, 1HNMR and MASS spectroscopy. In vivo screening for antihyperlipidemic activity in triton X-100 induced models showed moderate activity in comparison with standard.

Keywords: Thiadiazole, Antihyperlipidemia, Triton X-100, Atorvastatin.


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