Authors : MD Majeed Pasha, Shivalinga Swamy Salimath, Mohan Rao K.N, Mantha Satya Padmaja, Sujith Halappa
DOI : 10.18231/2581-4222.2018.0015
Volume : 3
Issue : 2
Year : 0
Page No : 50-55
Background: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and inflammation. It is now recognized to have systemic consequences that may affect morbidity and mortality. In patients with COPD, smoking is the major risk factor which affects the lipid profile.
The objective of this study was to evaluate serum levels of high-density lipoprotein (HDL) and triglycerides (TG) in patients with COPD and compare them with healthy non-smoking controls.
Methodology: This study was conducted in COPD patients with age and gender matched healthy controls. Both cases and controls were evaluated to obtain relevant history and clinical data. Spirometry and fasting lipid profile were performed in cases and controls; staging of COPD was based on Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2011 guidelines.
Results: Fifty one subjects diagnosed with COPD and an equal number of controls were recruited; this included 43 males and 8 females with a mean age of 57.3 years. The mean smoking index of COPD patients was 316.8. Seven (13.7%) patients had mild, 30(58.8%) had moderate, 12(23.5%) had severe and 2(3.9%) had very severe COPD.
Twelve (23.5%) patients each in the COPD and control group had elevated triglycerides; the mean level being 141.6 mg/dl in COPD patients and 136.3 mg/dl in controls. (p=0.53).Thirty one (60.7%) patients with COPD and 22(43.1%) controls had decreased HDL; mean level was 41.2mg/dl in COPD patients and 47.6mg/dl in controls. A statistically significant difference was found in serum HDL level between cases and controls. (p=0.009)
Conclusions: It can be concluded from this study that lipid profile derangements are common in patients with COPD compared to healthy non-smoking controls. Further, the hypothesis that COPD is a systemic disease is supported by our study.
Keywords: HDL; High density lipoprotein, LDL, Low density lipoprotein.