Authors : D. Maheswari, Prabha Ganapathy, Indira
DOI : 10.18231/2394-2754.2018.0041
Volume : 5
Issue : 2
Year : 0
Page No : 180-185
Introduction: Pre-eclampsia affects 3–5% of all pregnancies1-9 and is a leading cause of maternal morbidity and mortality (12% of all maternal deaths) and also leads to perinatal consequences. The initial pathological changes of preeclampsia begin in the late first trimester leading to chronic placental insufficiency. Hence prediction of preeclampsia in early gestation is of great interest, as early therapeutical intervention such as aspirin3-6 might reduce the risk of preeclampsia. So in our study, we aim to ascertain the role of mean arterial pressure (clinical), urine calcium creatinine ratio (biochemical) and uterine artery Doppler (radiological) parameters in predicting preeclampsia.
Aims and Objectives: To study mean arterial pressure, spot urine calcium creatinine ratio, Doppler of uterine artery between 20-24 weeks of gestational age as predictor of preeclampsia and to know the effectiveness of combination of above parameters in predicting preeclampsia.
Materials and Methods: It was a prospective study involving 100 low risk pregnant women of any parity with gestational age of 20-24 weeks. All study individuals were followed till term and the end point of the study was considered to be the development of preeclampsia as per the ACOG criteria 2013.
Results: All parameters (mean arterial pressure, urine calcium creatinine ratio and uterine artery Doppler) were individually found to be statistically significant predictor. Doppler of uterine artery was found to be a better predictor of preeclampsia when compared to mean arterial pressure and urine calcium creatinine ratio individually. Combination of all three parameters was found to be the better predictor than individual parameter.
Keywords: Preeclampsia, Mean arterial pressure, Urine calcium creatinine ratio and uterine artery Doppler.