Authors : Manisha G. Audi
DOI : 10.18231/2394-6377.2018.0042
Volume : 5
Issue : 2
Year : 0
Page No : 206-208
Oxygen free radicals generated during radiation injury damage human erythrocyte membrane proteins including spectrin and band 3 protein. Results show an appreciable degree of spectrin and band 3 protein loss of about 55-65% due to crosslinking, and proteolysis when sodium dodecyl sulphate polyacrylamide gel electrophoresis carried out on erythrocyte ghosts. Oxidative damage to membrane proteins lead to degradation of its cytoskeletal components.
Keywords: Spectrin, Band 3 protein, Erythrocyte ghosts, Oxygen free radicals