Analysis and characterization of cefixime by using IR, HPLC and gas chromatography

Authors : M. Prasada Rao, B. Rama Rao, M. Srikanth

DOI : 10.18231/2394-2797.2018.0012

Volume : 5

Issue : 2

Year : 0

Page No : 74-83

To develop a new, simple, sensitive, accurate, and economical analytical methods for the estimation of related compounds in Cefixime formulations. Validate the proposed methods in accordance with USP, EUROPE and ICH guidelines for the intended analytical application. Identify whether the given sample is Cefixime by IR spectroscopy and solubility test. To determine the wavenumber in cm-1 (reciprocal to wave length region) of given sample by Infrared Spectroscopy. To determine the moisture content present in the given sample of Cefixime by Karl Fischer method. Find out the assay and related substances (impurities) of given Cefixime by using the validated method with help of High performance Liquid Chromatography. Estimate the amount of Residual solvents by Gas Chromatography. The tests were performed as per the requirements of EUROPE monograph for Cefixime.

Keywords: Cefixime, IR, HPLC and gas chromatography


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